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KMID : 0363620100310030066
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Journal of Korean Oriental Medicine
2010 Volume.31 No. 3 p.66 ~ p.78
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Effects of Acupuncture at GB30, GB34, and BL40 on Functional Recovery after Sciatic Crushed Nerve Injury in Rats
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Lee Moon-Kyu
Song Yun-Kyung
Lim Hyung-Ho
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Abstract
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Background: Peripheral nerve injuries are a commonly-encountered clinical problem and often result in a chronic pain and severe functional deficits.
Objectives: The aim of this study was to evaluate the effects of acupuncture on the descending pain and the recovery of the locomotor function that follows sciatic crushed nerve injury in rats.
Method: In order to assess the effects of acupuncture on the descending pain and functional recovery, we investigated the walking track analysis, brain-derived neurotrophic factor (BDNF) and its receptor tyrosine receptor kinase B (TrkB) expression in the sciatic nerve, and on the expressions of c-Fos and nitric oxide synthase in the paraventricular nucleus (PVN) of the hypothalamus and in the ventrolateral periaqueductal gray (vlPAG) region resulting from sciatic crushed nerve injury in rats.
Results: Acupuncture treatment at Huantiao (GB30), Yanglingquan (GB34), and Weizhong (BL40) facilitated functional recovery. C-Fos and nitric oxide synthase expressions in the brain and BDNF and TrkB expressions in the sciatic nerve were decreased by acupuncture treatment. The most potent effects of acupuncture were observed at the GB30 acupoint.
Conclusion: It is possible that acupuncture can be used for pain control and functional recovery from sciatic nerve injury.
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KEYWORD
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Sciatic crushed nerve injury, Acupuncture, Functional recovery, Huantiao, Yanglingquan, Weizhong
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